Day 22 takes place in a world hit by a new and presently unknown infection which has wiped out most of the world's population. You are one of the few who have survived and now you must search this new wasteland in order to fight for your life against what is left of the indigenous population now infected with the disease. Go solo, team up with friends or take on the world, as you choose your path in this brutal and chilling landscape using whatever means you stumble upon to survive.
The player will have to fight both zombies and other players in order to survive. An important aspect of the game is the interactions between players, which can be hostile, marked by the exchanges of fire, or friendly, marked by cooperation and the exchanging of items , one of the focuses in the game is in staying fed, hydrated, dry, and healthy. Food is available in markets and homes, as well as wildlife. Water can be obtained in homes, markets, water sources, rivers, lakes, and sea. Food can become rotten and will sicken the player. Injury by shooting, melee weapons, zombie attacks, or falls may cause loss of blood, which can be recovered by consuming food or the use of medical equipment. hydration levels, food, and other "stats" can be accessed by the player's inventory.